Protective Mechanism of Ginsenoside CK on Liver Injury in Type 2 Diabetic Rats

YAN Shuang; LI Guangyao; DAI Congshu; CUI Haozhen; LIU Zhenyu; LIN Changqing

doi:10.13386/j.issn1002-0306.2020050104

Volume 42 Issue 2

Jan. 2021

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Science and Technology of Food Industry > 2021 > 42(2): 310-315. > DOI: 10.13386/j.issn1002-0306.2020050104

YAN Shuang, LI Guangyao, DAI Congshu, CUI Haozhen, LIU Zhenyu, LIN Changqing. Protective Mechanism of Ginsenoside CK on Liver Injury in Type 2 Diabetic Rats[J]. Science and Technology of Food Industry, 2021, 42(2): 310-315. DOI: 10.13386/j.issn1002-0306.2020050104

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Protective Mechanism of Ginsenoside CK on Liver Injury in Type 2 Diabetic Rats

Department of Traditional Chinese Medicine, School of Medicine, Yanbian University, Yanji 133000, China

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Received Date: May 08, 2020
Available Online: January 20, 2021

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Abstract

Objective:To explore the protective mechanism of ginsenoside CK on liver injury in type 2 diabetes(T2DM)rats. Methods:In this experiment,the T2DM rat model was established,the FBG of the rats was recorded,and OGTT test after 8 weeks of gavage. Detection of relevant indicators in serum,related indicators and levels of four inflammatory factors in liver tissue homogenate. Detection of liver tissue lesions by HE staining. Western Blot method was used to detect the expression of TLR/Myd88/NF-κB signaling pathway protein. Results:The group of ginsenoside CK could significantly reduced FBG levels in T2DM rats(P<0.05),restored its glucose tolerance level,increased the levels of TC,TG,LDL-C,ALT,AST,SOD,GSH,CAT significantly(P<0.05),reduced the expression levels of HDL-C,MDA,four inflammatory factors and TLR4,Myd88,p65 and p-IKB-α protein significantly(P<0.05),liver tissue morphology was restored. Conclusion:Ginsenoside CK could protect the liver injury of T2DM rats by reducing inflammation and oxidative stress,and regulate TLR/Myd88/NF-κB signaling pathway.
- ginsenoside CK,
- type 2 diabetes,
- liver injury,
- inflammation,
- TLR/Myd88/NF-κB

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[1]	Evans J M,Newton R W,Ruta D A,et al. Socio-economic status,obesity and prevalence of type 1 and type 2 diabetes mellitus[J]. Diabet Med,2010,17(6):478-480.
[2]	姜雅杰,何博韬,王畅,等. 壳寡糖复合固体饮料对2型糖尿病小鼠糖脂代谢紊乱的调节作用分析[J].食品工业科技,2020,41(5):268-273 ,327.
[3]	Riccardo M,Vivette D. Agati D,et al. New developments in the genetics,pathogenesis,and therapy of IgA nephropathy[J]. Kidney Int,2015,88(5):974-989.
[4]	杨文娟,程世蕊,马养民,等. 裂叶荨麻对糖尿病小鼠肝脏损伤的保护作用[J].食品工业科技,2019,40(11):313-317.
[5]	Ramírez-Pérez G,Sánchez-Chávez G,Salceda R. Mitochondrial bound hexokinase type I in normal and streptozotocin diabetic rat retina.[J]. Mitochondrion,2020,52:212-217.
[6]	Bruno G,Runzo C,Cavalloperin P,et al. Incidence of type 1 and type 2 diabetes in adults aged 30-49 years:The population-based registry in the province of Turin,Italy[J]. Diabetes Care,2005,28(11):2613-2619.
[7]	Holman N,Young B,Gadsby R. Current prevalence of Type I and Type 2 diabetes in adults and children in the UK[J]. Diabet Med,2015,32(9):1119-1120.
[8]	杨硕. 糖尿病肝损伤研究进展[C]//中华中医药学会内科分会.中华中医药学会第十三届内科肝胆病学术会议论文汇编.中华中医药学会内科分会:中华中医药学会,2008:218-222.
[9]	Man L,Dongsheng Y,Qingsong S,et al. Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4/NF-kB/NLRP3 pathway[J]. J Cell Biochem,2020,121(4):2994-3004.
[10]	刘彦楠. 人参皂苷Rg5的制备及其抗胃癌和乳腺癌活性研究[D].西安:西北大学,2019.
[11]	毕云枫,陶伟明,王溪竹,等. 人参皂苷Rh1对AD小鼠认知障碍的改善作用[J].食品工业科技,2019,40(24):300-304.
[12]	孟雪,邱智东,王蕾,等. 人参皂苷CK抑制人结肠癌SW480细胞增殖的机制研究[J].中草药,2020,51(6):1567-1574.
[13]	刘博,俞婷,韩晓蕾,等. 人参皂苷抗炎作用及其分子机制的研究进展[J].中国药学杂志,2019,54(4):253-258.
[14]	安丽萍. 人参皂苷CK改善2型糖尿病大鼠骨骼肌胰岛素抵抗作用[C]//中国药理学会补益药药理专业委员会.第三届中国药理学会补益药药理专业委员会学术研讨会论文集.中国药理学会补益药药理专业委员会:中国药理学会,2013:6-7.
[15]	刘妮,安丽萍. 人参皂苷CK对2型糖尿病大鼠肾脏的保护作用[J].北华大学学报(自然科学版),2019,20(3 ):315-319.
[16]	曹文贵,王慕琪,吴建鸿,等. 丙型肝炎患者血清IL-1α、IL-6、TNF-α、IFN-γ的检测及意义[J]. 临床肝胆病杂志,2000(3):161-163.
[17]	Saha M R,Dey P,SarkarI,et al. Acacia nilotica leaf improves insulin resistance and hyperglycemia associated acute hepatic injury and nephrotoxicity by improving systemic antioxidant status in diabetic mice[J]. J Ethnopharmacol,2018,210:275-286.
[18]	李伟. 人参皂苷Compound K对2型糖尿病的降血糖作用及肝糖异生信号转导通路调控[D].长春:吉林大学,2012.
[19]	张宇,王洪波,朱振宇,等. 人参皂苷CK抑制内质网应激防治酒精性肝损伤[J].安徽医科大学学报,2019,54(5):710-715.
[20]	李秋云,王彩宁,史丽萍,等. 2型糖尿病及前期患者胰岛素抵抗与脂代谢紊乱的关系[J].中国全科医学,2011(24):2716-2719.
[21]	杨鑫,刘明辉,马越娇,等. 复方中药组分抗胰岛素抵复方中药组分抗胰岛素抵抗糖尿病大鼠糖的过氧化作用[J].中国当代医药,2018,25(33):33-36.
[22]	唐俊,左满花. 人参皂苷Rg3对糖尿病肾脏疾病大鼠氧化应激和凋亡的影响[J].中国糖尿病杂志,2017,25(10):929-932.
[23]	刘伟,祝海锐,李佳,等. 他汀类药物对2型糖尿病的疗效及炎性因子的影响[J].解放军医药杂志,2020,32(2):64-66.
[24]	李冀,车思桦,关迪新,等. 2型糖尿病胰岛素抵抗机制及中医药治疗研究[J].辽宁中医药大学学报,2019(11):5-8.
[25]	沈安鲁,施慧,彭代银,等. 桃红四物汤调节NF-κB信号通路保护2型糖尿病模型大鼠心脏结构和功能[J].中华中医药杂志,2019(4):1359-1362.
[26]	单佳铃,魏荣锐,王陆,等. 基于TLR2/MyD88/NF-κB和NALP3信号通路探讨藏族药短穗兔耳草提取物抗慢性酒精性肝损伤大鼠的作用机制[J].中国实验方剂学杂志,2020,26(2):80-85.
[27]	刘婷婷. 枸杞多糖经TLR4/MyD88/NF-κB信号通路对T2DM炎症因子的作用[D].银川:宁夏医科大学,2019.
[28]	Paudel Y N,Ali M R,Adil M,et al. "2-(4-Fluorobenzamido)-4-methylthiazole-5-carboxy-lic acid" a novel thiazole compound,ameliorates insulin sensitivity and hyperli-pidaemia in streptozotocin-induced diabetic rats:Plausible role of inflammatory and oxidativestress markers[J]. Biomed Pharm,2017,95:1232-1241.

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