Citation: | XIE Bo, FU Hong, YANG Fang. Research Progress on Preparation,Purification,Identification and Structure-Activity Relationship of Bioactive Peptides[J]. Science and Technology of Food Industry, 2021, 42(5): 383-391. DOI: 10.13386/j.issn1002-0306.2020050012 |
[1] |
王克全,徐寒梅.多肽类药物的研究进展[J].药学进展,2015,39(9):642-650.
|
[2] |
陈哲. 银杏多肽的提取、分离纯化及体内抗氧化活性研究[D].合肥:合肥工业大学,2012.
|
[3] |
Chen Z Q,Li W W,Ramesh K S,et al. Bioactive peptide with antioxidant and anticancer activities from black soybean[Glycine max(L.)Merr.]byproduct:Isolation,identification and molecular docking study[J]. European Food Research and Technology,2019,245(3):677-689.
|
[4] |
李勇. 生物活性肽研究现况和进展[J].食品与发酵工业,2007,33(1):3-9.
|
[5] |
曲朋,宋利,赵好冬,等. 多肽合成研究进展[J].中国现代中药,2015,17(3):285-289
,295.
|
[6] |
高彩霞. 一种发色多肽底物的化学合成及其评价[D].上海:华中科技大学,2019.
|
[7] |
王丹. 奥曲肽的液相合成及氨基酸保护基的研究[D].沈阳:沈阳药科大学,2006.
|
[8] |
李士杰,杨洋,崔营营,等. 微通道连续流动高效绿色合成亮丙瑞林[J].高等学校化学学报,2020,41(7):1559-1566.
|
[9] |
喻蓬秋. 天然化学连接应用于环肽合成及多肽N-端半胱氨酸的保护方法研究[D].南昌:南昌大学,2018.
|
[10] |
蓝欢. 酰肼连接法合成具有镇痛效果的曼巴蛇毒肽[D]. 北京:清华大学,2016.
|
[11] |
丁靖. 胡蜂毒肽-M和麦角环肽的合成研究[D].成都:西南交通大学,2019.
|
[12] |
莫金秋,刘泰容,苏春丽,等.软刀素肽的固相合成[J].华西药学杂志,2018,33(4):356-358.
|
[13] |
陆春兰,陈璇,张丰,等. 糙耳孔蜈蚣毒素多肽STX-Osp1的基因工程制备[J]. 生物技术世界,2015(11):22-24.
|
[14] |
金瑞美. 基于基因工程多肽的可注射杂化水凝胶的制备及其在肿瘤治疗中的应用[D].武汉:华中科技大学,2019.
|
[15] |
Li XH,Fan Y,Lin Q,et al. Expression of chromogranin A-derived antifungal peptide CGA-N12 in Pichia pastoris[J]. Bioengineered,2020,11(1):318-327.
|
[16] |
贾韶千,李艳霞.黄鳝鱼骨多肽制备及其抗氧化活性[J].食品科学,2016,37(1):133-138.
|
[17] |
李杨,齐宝坤,隋晓楠,等. 超声辅助酶解制备红豆多肽及其抗氧化性的研究[J]. 食品工业科技,2016,37(1):232-237.
|
[18] |
Zhang F,Qu J,Kiran T,et al. Purification and identification of an antioxidative peptide from peony(Paeonia suffruticosa Andr.)seed dreg[J]. Food Chemistry,2019,285:266-274.
|
[19] |
徐阳,孙强,青维,等. 复合酶法制备大鲵多肽的研究[J].食品工业科技,2015,36(24):180-185.
|
[20] |
何秋实. 超声辅助复合酶法制备核桃抗氧化肽工艺研究[J].粮食与油脂,2018,31(5):97-100.
|
[21] |
蔡彬新,周逢芳,林则圣. 复合酶法制备海参内脏ACE抑制肽工艺研究[J]. 广东农业科学,2016,43(12):85-89.
|
[22] |
江磊,赵换,陶燕铎,等. 二维制备高效液相色谱分离塞隆骨强极性多肽[J]. 天然产物研究与开发,2015,27(7):1205-1209.
|
[23] |
李文龙,张慧,汤琦,等. 高效液相色谱在多肽分离分析中的应用[J]. 分析仪器,2018(1):63-67.
|
[24] |
Toll H,Oberacher H,Swart R,et al. Separation,detection,and identification of peptides by ion-pair reversed-phase high-performance liquid chromatography-electrospray ionization mass spectrometry at high and low pH[J]. Journal of ChromatographyA,2005,1079(1-2):274.
|
[25] |
高杨,赵红玲,王良友,等. 反相高效液相色谱法分离纯化固相化学合成布舍瑞林[N]. 承德医学院学报,2016,33(2):143-144.
|
[26] |
Piovesana S,Montone C M,Cavaliere C,et al. Sensitive untargeted identification of short hydrophilic peptides by high performance liquid chromatography on porous graphitic carbon coupled to high resolution mass spectrometry[J]. Journal of Chromatography A,2018,1059:73-79.
|
[27] |
赵静. 林蛙胶原蛋白多肽的分离纯化、功能性研究及其微胶囊的制备[D]. 长春:吉林大学,2019.
|
[28] |
姜宁,张双健,朱静,等. 一种新型马鹿茸多肽纯化、鉴定及体外降血糖活性[J]. 中国药科大学学报,2016,47(3):363-367.
|
[29] |
陈思远,刘永祥,曹小舟,等. 从麦胚清蛋白分离制备高活性抗氧化肽[J]. 中国农业科学,2016,49(12):2379-2388.
|
[30] |
颜辉,张琦,江明珠,等. 麦胚降血糖肽的分离纯化及鉴定[J]. 食品科学,2018,39(20):92-98.
|
[31] |
孙甜. 油菜蜂花粉可逆糖化多肽的纯化、鉴定及其免疫组化定位[D]. 西安:西北大学,2016.
|
[32] |
Zhang W W,Jiang X Z,Zhao S,et al. A polysaccharide-peptide with mercury clearance activity from dried fruiting bodies of maitake mushroom Grifola frondosa[J].Scientific Reports,2018,8(1):1-9.
|
[33] |
刘云姣. 南极磷虾中含氟多肽的分离纯化及其结构研究[D].上海:上海海洋大学,2019.
|
[34] |
柳青. 基于UPLC和加压毛细管电色谱平台的两种超高效分离技术的研究及在生物分子分析中的应用[D].上海:上海交通大学,2019.
|
[35] |
Chen D Y,Katelyn R L,Oleg V. K,et al. Capillary zone electrophoresis-tandem mass spectrometry for large-scale phosphoproteomics with the production of over 11,000 phosphopeptides from the colon carcinoma HCT116 cell line[J]. Analytical Chemistry,2019,91(3):2201-2208.
|
[36] |
Wang W,Bai R,Cai X,et al. Separation and determination of peptide metabolite of Bacillus licheniformis in a microbial fuel cell by high:Peed capillary micellar electrokinetic chromatography[J].Journal of Separation Science,2017,40(22):4446-4452.
|
[37] |
刘琳. 功能性食品中多肽的分离分析方法研究[D].泰安:山东农业大学,2013.
|
[38] |
徐莉莉. 新型镍离子亲和色谱介质的制备及其在含组氨酸多肽中的应用[D].西安:西北大学,2016.
|
[39] |
Aderonke I O,Olufunmilayo S O,Victor N E,et al. Pigeon pea enzymatic protein hydrolysates and ultrafiltration peptide fractions as potential sources of antioxidant peptides:An in vitro study[J]. LWT,2018,97:269-278.
|
[40] |
He R,Girgih A T,Rozoy E,et al. Selective separation and concentration of antihypertensive peptides from rapeseed protein hydrolysate by electrodialysis with ultrafiltration membranes[J]. Food Chemistry,2016,197(A):1008-1014.
|
[41] |
黄莹莹. 固定化酶制备牡蛎ACE抑制肽及抗氧化肽[D].哈尔滨:哈尔滨工业大学,2013.
|
[42] |
谢昕,钱春,刘邵鹏.双水相萃取技术在生物分离提取中的应用研究进展[J].科学大众(科学教育),2015(11):150-160.
|
[43] |
曾颖.[Cnmim]N(CN)2/Ac(n=2,4,6,8)离子液体双水相萃取分离木瓜蛋白酶的研究[D].海口:海南大学,2018.
|
[44] |
Jiang B,Zhang X,Yuan Y,et al. Separation of antioxidant peptides from pepsin hydrolysate of whey protein isolate by ATPS of EOPO Co-polymer(UCON)/phosphate[J]. Scientific Reports,2017,7(1):13320-13332.
|
[45] |
Jiang B,Na J,Wang L L,et al. Separation and enrichment of antioxidant peptides from whey protein isolate hydrolysate by aqueous two-phase extraction and aqueous two-phase flotation[J]. Foods(Basel,Switzerland),2019,8(1):34-40.
|
[46] |
刘让东,许歆瑶,王薇薇,等.固化pH梯度毛细管等电聚焦整体柱的制备及在蛋白质等电点分析中的应用[J].色谱,2019,37(10):1090-1097.
|
[47] |
魏娟,谷雪,王彦,等.毛细管等电聚焦/加压毛细管电色谱二维分离体系在多肽分离中的应用[J].分析化学,2011,39(2):188-192.
|
[48] |
吴漪. 加压毛细管电色谱二维联用技术的研究及其在复杂体系分离中的应用[D]. 上海:上海交通大学,2011.
|
[49] |
Marcel K,Dennis K,Marcus W,et al. Application of displacement chromatography to online two-dimensional liquid chromatography coupled to tandem mass spectrometry improves peptide separation efficiency and detectability for the analysis of complex proteomes[J]. Analytical Chemistry,2018,90(16):9951-9958.
|
[50] |
Xing L J,Hu Y Y,Hu H Y,et al. Purification and identification of antioxidative peptides from dry-cured Xuanwei ham[J]. Food Chemistry,2016,194(1):951-958.
|
[51] |
周名洋,何雨欣,孙杨赢,等. 鹅骨胶原钙螯合肽的分离纯化及结构鉴定[J/OL].食品科学:1-13[2020-06-29
]. http://kns.cnki.net/kcms/detail/11.2206.ts.20200416.1758.002.html.
|
[52] |
姜海洋. 牦牛骨抗氧化胶原多肽的制备及其分离纯化和鉴定[D].成都:四川农业大学,2018.
|
[53] |
Peter Böhlen,Castillo F,Ling N,et al. Purification of peptides:an efficient procedure for the separation of peptides from amino acids and salt[J]. Chemical Biology & Drug Design,2010,16(4):306-310.
|
[54] |
Gilar M,Olivova P,Daly A E,et al. Two-dimensional separation of peptides using RP-RP-HPLC system with different pH in first and second separation dimensions[J]. Journal of Separation Science,2005,28(14):1694-1703.
|
[55] |
张亚,苏品,廖晓兰,等. 多肽的分离纯化技术研究进展[J].微生物学杂志,2013,33(5):87-91.
|
[56] |
徐小华,陈天豹,李珑,等. 一种改进的小分子多肽SDS-PAGE方法[J].福州大学学报:自然科学版,2001(3):113-115.
|
[57] |
刘云姣,张海燕,刘淑晗,等. 响应面优化南极磷虾蛋白酶解工艺及蛋白肽组分分析[J]. 现代食品科技,2019,35(1):144-151.
|
[58] |
马歇克著,朱厚础译. 蛋白质纯化与鉴定实验指南[M]. 2002年版.北京:科学出版社,2002:77.
|
[59] |
Wang X Q,Yu H H,Xing R G,et al. Purification and identification of antioxidative peptides from mackerel(Pneumatophorus japonicus)protein[J]. Rsc Advances,2018,8(37):20488-20498.
|
[60] |
高威芳,何魁芳,朱鹏,等. 活性多肽序列结构分析鉴定技术的研究进展[J]. 生物技术,2016,26(2):199-204.
|
[61] |
Zhang J N,Zhao M M,Su G W,et al. Identification and taste characteristics of novel umami and umami-enhancing peptides separated from peanut protein isolate hydrolysate by consecutive chromatography and UPLC-ESI-QTOF-MS/MS[J]. Food Chemistry,2019:674-682.
|
[62] |
Hood B L,Veenstra T D,Conrads T P. Mass spectrometry-based proteomics[J]. International Congress,2004,1266(6928):375-380.
|
[63] |
陈文章. 微流控芯片Edman降解及在蛋白质测序中的应用研究[D].杭州:浙江大学,2008.
|
[64] |
杨林. 黄海葵毒素多肽的分离纯化及功能鉴定[D].舟山:浙江海洋学院,2012.
|
[65] |
刘伟慧. 森林山蛭(Hameadipsa sylvestris)抗血栓多肽的分离纯化、结构与功能研究[D]. 南京:南京农业大学,2015.
|
[66] |
贺磊. 魔芋ACE抑制肽制备技术及理化性质研究[D].西安:陕西科技大学,2017.
|
[67] |
崔凤杰,孙文敬,张玲,等. 小麦面筋多肽D-WG-0-Ⅰ的分离纯化与结构鉴定[J]. 食品科技,2012(11):164-168.
|
[68] |
冯晓梅,韩玉谦,赵志强,等. 牡蛎酶解产物中多肽的分离纯化及其结构研究[J]. 中国海洋药物,2009(2):1-5.
|
[69] |
Jigni M,Rakhee R,Kaushlesh S,et al. Antioxidant-rich peptide fractions derived from high-altitude chinese caterpillar medicinal mushroom ophiocordyceps sinensis(ascomycetes)inhibit bacterial pathogens[J]. International Journal of Medicinal Mushrooms,2019,21(2):155-168.
|
[70] |
Jia W Z,Peng Q,Su L N,et al. Novel bioactive peptides from meretrix meretrix protect caenorhabditis elegans against free radical-induced oxidative stress through the stress response factor DAF-16/FOXO[J]. Marine Drugs,2018,16(11):444-450.
|
[71] |
Young K M,Yeong J G,Jeong L Y,et al. Identification of anti-inflammatory active peptide from black soybean treated by high hydrostatic pressure after germination[J]. Phytochemistry Letters,2018,27:167-173.
|
[72] |
Mahta M,Saeed M,Maliheh S. Structural analysis of ACE-inhibitory peptide(VL-9)derived from Kluyveromyces marxianus protein hydrolysate[J]. Journal of Molecul-ar Structure,2020,1213.
|
[73] |
范三红,王娇娇,李佳妮,等.辣椒红色素和辣椒碱体内抗氧化活性及降血脂功能研究[J/OL].食品科学:1-9[2020-04-14
].http://kns.cnki.net/kcms/detail/11.2206.ts.20200330.1508.072.html.
|
[74] |
Pak V V,Koo M,Lee N,et al. Structure-activity relationships of the peptide Ile-Ala-Val-Pro and its derivatives revealed using the semi-empirical AM1 method[J]. Chemistry of Natural Compounds,2005,41(4):454-460.
|
[75] |
李华亮,王碧雪,丁玉梅,等.暹罗鳄多肽粉对小鼠机体免疫力及抗疲劳效应的增强作用[J].厦门大学学报:自然科学版,2019,58(5):707-711.
|
[76] |
Solstad R G,Johansen C,Stensvåg K,et al. Structure-activity relationship studies of shortened analogues of the antimicrobial peptide EeCentrocin 1 from the sea urchin Echinus esculentus[J].Journal of Peptide Science:an Official Publication of the European Peptide Society,2020,26(2).
|
[77] |
Hou T,Lu Y L,Guo D J,et al. A pivotal peptide(Val-Ser-Glu-Glu)from duck egg white promotes calcium uptake and structure-activity relationship study[J]. Journal of Functional Foods,2018,48:448-456.
|
[78] |
Ifeanyi D,Nwachukwu,Rotimi E A. Structural and functional properties of food protein-derived antioxidant peptides[J]. Journal of Food Biochemistry,2019,43(1):e12761.
|
[79] |
Li Z Y,Zhao S,Xin X D,et al. Purification,identification and functional analysis of a novel immunomodulatory peptide from silkworm pupa protein[J]. International Journal of Peptide Research and Therapeutics,2019,26(3):633-637.
|
1. |
曲美霖,胡俊君,程哲,李云龙. 绿豆预熟化工艺及品质研究进展. 食品与机械. 2024(02): 227-232 .
![]() | |
2. |
张亮,崔燕,邵兴锋,宣晓婷,董翼飞,沈佳峰,凌建刚. 籼粳杂交稻变温-缓苏干燥工艺优化及蛋白结构研究. 食品工业科技. 2024(14): 165-174 .
![]() | |
3. |
吴文青,钱海峰,李言,樊铭聪,王立. 烘焙用乳化剂研究进展. 食品与发酵工业. 2024(15): 389-397 .
![]() | |
4. |
赵康程,李森,谭斌,吴娜娜. 不同加工方式对谷物及豆类蛋白结构、功能特性的影响研究进展. 中国粮油学报. 2024(10): 198-206 .
![]() | |
5. |
李娇,梁雅琪,王景雪,李晨. 白酒糟醇溶蛋白的磷酸化改性及功能性质. 食品工业科技. 2023(09): 60-67 .
![]() | |
6. |
刁静静,陶阳,国慧,陈洪生,王长远,张东杰,朱永胜. 加热温度对牡荆素-绿豆蛋白互作物结构和功能性的影响. 中国食品学报. 2023(08): 197-207 .
![]() | |
7. |
林瑞榕,陈佳琪,刘思迪,郭泽镔. 食物在烹饪过程中有害物质形成与减控技术研究进展. 食品安全质量检测学报. 2021(22): 8918-8926 .
![]() |