Effect of Chicory Polysaccharide on Immune Function in Immunosuppressed Mice

WU Yulong; ZHU Hua; ZHANG Yilin; JIANG Haitao; HUA Chun

doi:10.13386/j.issn1002-0306.2020030168

Volume 42 Issue 3

Jan. 2021

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Science and Technology of Food Industry > 2021 > 42(3): 284-289,337. > DOI: 10.13386/j.issn1002-0306.2020030168

WU Yulong, ZHU Hua, ZHANG Yilin, JIANG Haitao, HUA Chun. Effect of Chicory Polysaccharide on Immune Function in Immunosuppressed Mice[J]. Science and Technology of Food Industry, 2021, 42(3): 284-289,337. DOI: 10.13386/j.issn1002-0306.2020030168

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Effect of Chicory Polysaccharide on Immune Function in Immunosuppressed Mice

1. School of Food Science, Nanjing Xiaozhuang University, Nanjing 211171, China;
2. Jiangsu Provincial Key Construction Laboratory of Special Biomass Waste Resource Utilization, Nanjing 211171, China;
3. Jiangsu Second Normal College, Nanjing 210013, China

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Received Date: March 15, 2020
Available Online: February 02, 2021

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Abstract

Abstract

Objective:To study the effect of chicory polysaccharide on immune function in immunosuppressed mice. Methods:ICR mice were randomly divided into blank group,model group,drug group(Piantai),CP low,medium and high dose group. In addition to the blank group,the other groups used cyclophosphamide to cause immunosuppressed mouse model. Body weight,immune organ index,peripheral blood leukocytes and erythrocyte count,delayed hypersensitivity-induced toe swelling,peritoneal macrophage phagocytosis,serum levels of lysin and activity levels of interleukin 2(IL-2),interleukin 6(IL-6)and tumor necrosis factor α(TNF-α)in each group of mice were determined,respectively. Results:Compared with the model group,CP high dose group could significantly increase net body weight rate,immune organ index,macrophage phagocytosis rate and index,number of leukocytes and erythrocyte,and decrease toe swelling in immunosuppressed mice(P<0.05). Meanwhile,CP high dose group could also significantly improve phagocytosis of mouse peritoneal macrophages,serum lysin content,and regulate immune cytokines in immunosuppressed mice. Conclusion:CP could enhance immune activity in immunosuppressed mice.
- chicory polysaccharide,
- immunosuppressed,
- immune activity,
- regulation

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References

[1]	Chen S J,Li J Y,Zhang J M.Extraction of yellow pear residue polysaccharides and effects on immune function and antioxidant activity of immunosuppressed mice[J].International Journal of Biological Macromolecules,2019,126:1273-1281.
[2]	Zhao T,Feng Y,Li J,et al. Schisandra polysaccharide evokes immunomodulatory activity through TLR 4-mediated activation of macrophages[J].International Journal of Biological Macromolecules,2014,65:33-40.
[3]	Gong Y,Wu J,Li S T.Immuno-enhancement effects of Lycium ruthenicum Murr.polysaccharide on cyclophosphamide-induced immunosuppression in mice[J].International Journal of Clinical and Experimental Medicine,2015,8(11):20631-20637.
[4]	Cho C W,Han C J,Rhee Y K,et al. Cheonggukjang polysaccharides enhance immune activities and prevent cyclophosphamide-induced immunosuppression[J].International Journal of Biological Macromolecules,2015,72:519-525.
[5]	Huang J Q,Nie Q X,Liu X Z,et al. Ganoderma atrum polysaccharide modulates TNF-α secretion and mRNA expression in macrophages of S-180 tumor-bearing mice[J].Food Hydrocolloids,2016,53:24-30.
[6]	Zhang Y,Li Q,Shu Y M,et al. Induction of apoptosis in S180 tumour bearing mice by polysaccharide from Lentinus edodes via mitochondria apoptotic pathway[J].Journal of Functional Foods,2015,15:151-159.
[7]	Liu Z G,Xing J,Zheng S S,et al. Ganoderma lucidum polysaccharides encapsulated in liposome as an adjuvant to promote Th1-bias immune response[J].Carbohydrate Polymers,2016,142:141-148.
[8]	Wang J,Ge B,Li Z,et al. Structural analysis and immunoregulation activity comparison of five polysaccharides from Angelica sinensis[J]. Carbohydrate Polymers,2015,140:6-12.
[9]	Zhao X N,Sun W J,Zhang S J,et al. The immune adjuvant response of polysaccharides from Atractylodis macrocephalae Koidz in chickens vaccinated against Newcastle disease(ND)[J]. Carbohydrate Polymers,2016,141:190-196.
[10]	Li J,Qian W,Xu Y H,et al. Activation of RAW 264.7 cells by a polysaccharide isolated from Antarctic bacterium Pseudoaltermonas sp.S-5[J].Carbohydrate Polymers,2015,130:97-103.
[11]	Graziani G,Ferracane R,Sambo P,et al. Profiling chicory sesquiterpene lactones by high resolution mass spectrometry[J].Food Research International,2015,67:193-198.
[12]	Tardugno R,Pozzebon M,Beggio M,et al. Polyphenolic profile of Cichorium intybus L.endemic varieties from the Veneto region of Italy[J].Food Chemistry,2018,266:175-182.
[13]	Maia Campos P M B G,G Mercurio D,O Melo M,et al. Cichorium intybus root extract:A "vitamin D-like" active ingredient to improve skin barrier function[J].Journal of Dermatological Treatment,2017,28(1):78-81.
[14]	付爱叶,王俏娜,吴雨龙,等.菊苣多糖体外抗氧化能力及抗疲劳作用[J].食品工业科技,2018,39(9):1-5 ,10.
[15]	Wu Y L,Zhou F,Jiang H T,et al. Chicory(Cichorium intybus L.)polysaccharides attenuate high-fat diet induced non-alcoholic fatty liver disease via AMPK activation[J].International Journal of Biological Macromolecules,2018,118:886-895.
[16]	Farhangi M A,Javid A Z,Dehghan P.The effect of enriched chicory inulin on liver enzymes,calcium homeostasis and hematological parameters in patients with type 2 diabetes mellitus:A randomized placebo-controlled trial[J].Primary Care Diabetes,2016,10(4):265-271.
[17]	Lin W Q,Liu C Q,Yang H,et al. Chicory,a typical vegetable in Mediterranean diet,exerts a therapeutic role in established atherosclerosis in apolipoprotein E-deficient mice[J].Molecular Nutrition & Food Research,2015,59(9):1803-1813.
[18]	Shimamura M,Kamijo S I,Illarionov P.Invariant natural killer T cells stimulated with cholesteryl glycosides modulate immune responses in allergy and delayed-type hypersensitivity[J].European Journal of Immunology,2019,49(2):348-350.
[19]	Zou M,Chen Y L,Sun-Waterhouse D,et al. Immunomodulatory acidic polysaccharides from Zizyphus jujuba cv.Huizao:Insights into their chemical characteristics and modes of action[J].Food Chemistry,2018,258:35-42.
[20]	王崇英,侯岁稳,高欢欢.细胞生物学实验[M].4版.北京:高等教育出版社,2017:86-89.
[21]	Cui H Y,Wang C L,Wang Y R,et al. Pleurotus nebrodensis polysaccharide(PN-S)enhances the immunity of immunosuppressed mice[J].Chinese Journal of Natural Medicines,2015,13(10):760-766.
[22]	Li Q,Chen G Y,Chen H,et al. Se-enriched G.frondosa polysaccharide protects against immunosuppression in cyclophosphamide-induced mice via MAPKs signal transduction pathway[J].Carbohydrate Polymers,2018,196:445-456.
[23]	Brekke O L,Christiansen D,Kisserli A,et al. Key role of the number of complement receptor 1 on erythrocytes for binding of Escherichia coli to erythrocytes and for leukocyte phagocytosis and oxidative burst in human whole blood[J].Molecular Immunology,2019,114:139-148.
[24]	Sun Y,Asmal M,Lane S,et al. Antibody-dependent cell-mediated cytotoxicity in Simian immunodeficiency virus-infected rhesus monkeys[J].Journal of Virology,2011,85(14):6906-6912.
[25]	Zhao L,Ashraf M A.Influence of silver-hydroxyapatite nanocomposite coating on biofilm formation of joint prosthesis and its mechanism[J].The West Indian Medical Journal,2015,64(5):506-513.
[26]	Khan H A,Ibrahim K E,Alrashood S T,et al. Immunohistochemistry of IL-1β,IL-6 and TNF-α in spleens of mice treated with gold nanoparticles[J].Saudi Journal of Biological Sciences,2020,27(4):1163-1168.
[27]	Nazimek K,Bustos-Morán E,Blas-Rus N,et al. Syngeneic red blood cell-induced extracellular vesicles suppress delayed-type hypersensitivity to self-antigens in mice[J].Clinical & Experimental Allergy,2019,49(11):1487-1499.
[28]	Chen X M,Nie W J,Fan S R,et al. A polysaccharide from Sargassum fusiforme protects against immunosuppression in cyclophosphamide-treated mice[J].Carbohydrate Polymers,2012,90(2):1114-1119.