Preparation and Biological Activity of Gold Nanoparticles Modified by Cordycepin Derivative

Objective:A new compound of 5'-furanoyl ester-3'-deoxyadenosine(compound B)was prep synthesized with cordycepin(compound A)as the raw material,complex C of gold nanoparticles modified by compound B was prepared,and antitumor activity and bacteriostatic activity in vitro were studied. Methods:The structure of compound B was confirmed by ¹H NMR,¹³C NMR and MS. The structure and morphology of complex C were characterized by infrared(IR),ultraviolet-visible spectrophotometer,X-ray diffraction(XRD),and transmission electron microscope(TEM). Results:The structures of compound B and complex C were characterized by IR and NMR,and synthesized successfully. MTT experiments showed that compound A,compound B,and complex C had significant inhibitory effects on the proliferation of HepG2 cells. The results of bacteriostatic experiment showed that all of them had significant bacteriostatic effects on E. coli,Bacillus subtilis,and Staphylococcus aureus. The antibacterial properties of complex C were investigated. The results showed that the minimum inhibitory concentrations of E. coli,B. subtilis,and S. aureus were 30,7.5 and 30 μg/mL,respectively.Conclusion:The research of this paper provides a new idea for the research of new antitumor antibacterials.