Effect of Theaflavins and Theabrownines on the Uric Acid Contents in a New Mice Model of Chronic Hyperuricemia

To investigate the reducing effects of theaflavins and theabrownine on the uric acid level,the chronic hyperuricemia model was established by feeding special diet to the mice. Then the mice in treatment groups were intragastrically administered with different concentrations of theaflavins and theabrownine for 21 days. At the end of treatment,blood was taken to detect uric acid content and total cholesterol(TCHO),glucose(GLU),triglyceride(TG),adenylate dehydrogenase(ADA),creatinine(CRE),alanine aminotransferase(ALT)andaspartate aminotransferase(AST)index. The results showed that,compared with the normal group,the serum uric acid contents of the model group significantly increased by 45%(P<0.01),which suggested the model was successfully established. Compared with the model group,the serum uric acid,AST content extremly signifieant reduced(P<0.01),while ADA,CRE,ALT contents in the mice of theaflavin treated group(800 mg/kg)were significantly reduced(P<0.05). The serum ADA and ALT contents in the mouse of theaflavin treated group(200 mg/kg)were significantly lower than those of the model group(P<0.05),extremly significant reduced serum AST content(P<0.01). The theabrownine treatment had negligible increasing effect on the uric acid contents,while a protective effects on the heart and kidney of the mice were observed. Thus,theaflavins have a significant effect on decreasing the contents of uric acid in chronic hyperuricemia mice,and theabrownine have no effect on decreasing the contents of uric acid in chronic hyperuricemia mice.