Effects of Astragalus Polysaccharide on Life Span and Antioxidation of Drosophila melanogaster

In order to explore the effect of Astragalus polysaccharide on the life span and antioxidation of D. melanogaster,different concentrations of Astragalus polysaccharide(0.1,0.5,1.0,1.5,2.0 μg/mL)were fed to D. melanogaster. Life span was studied through survival experiment,exercise capacity was studied through negative geotaxis capability experiment,and SOD,T-AOC and MDA activities were determined through antioxidant activity experiment. The results showed that,when Astragalus polysaccharide concentration was 1.0 μg/mL,the average life span of female and male D. melanogaster were prolonged by 27.69% and 25.77% compared with the control. Half death time was prolonged by 52.09% and 53.65%,respectively. The maximum life span was extended by 16.71% and 15.78% respectively,which were significantly higher than the control(P<0.05).Female and male D. melanogaster had the strongest ability to negative geotaxis capability,increased by 14.16% and 27.97% respectively,which were significantly higher than the control(P<0.05). In male and female D. melanogaster,T-AOC and SOD activities were the highest,while MDA contents was the lowest. Astragalus polysaccharide could significantly improve life span,exercise capacity and antioxidant capacity of D. melanogaster.