Fermentation Conditions Optimization of a Two-stage Culture for Enhancing Production of Lycopene by <i>Neurospora crassa</i> Using Response Surface Methodology

QUE Fa-xiu; CHEN Gang; GUO Yue-shan; ZHENG Shu-dan; JIAN Su-ping; WAN Ling

doi:10.13386/j.issn1002-0306.2019.17.023

QUE Fa-xiu, CHEN Gang, GUO Yue-shan, ZHENG Shu-dan, JIAN Su-ping, WAN Ling. Fermentation Conditions Optimization of a Two-stage Culture for Enhancing Production of Lycopene by Neurospora crassa Using Response Surface Methodology[J]. Science and Technology of Food Industry, 2019, 40(17): 142-147. DOI: 10.13386/j.issn1002-0306.2019.17.023

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Fermentation Conditions Optimization of a Two-stage Culture for Enhancing Production of Lycopene by Neurospora crassa Using Response Surface Methodology

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The effect of two-stage culture method(by combing shake culture with static culture)on lycopene production was studied in this study. Through Box-behnken experimental design and response surface methodology,the optimum conditions were shake culture 19 h,static culture 87 h,the concentration of medium 35 g/L,inoculum size of 5%,culture temperature 30℃ and bottle shaking rate 100 r/min. Under this conditions,the dry cell weight decreased by 23.54% and lycopene production increased by 102.54% compared with conventional shake culture.

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Fermentation Conditions Optimization of a Two-stage Culture for Enhancing Production of Lycopene by Neurospora crassa Using Response Surface Methodology

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