Optimization of Preparation Process of Calcium Carbonate Solid Lipid Particles and Its Compression Performance and Sensory Characteristics

Solid lipid particles(SLP)were prepared by phase-inversion and emulsification to encapsulate the calcium carbonate,designed to improve the sensory acceptability of calcium carbonate. The orthogonal test was used to optimize the preparation conditions including sodium caseinate concentration,agitation speed,emulsifying time and ratio of aqueous phase to oil phase. The Carr's flow ability index of premixed powder was tested to evaluate the compressibility and flow ability of SLP loaded calcium carbonate,and the tensile strength and sensory property of the calcium chewable tablets of different calcium sources were investigated. The optimum conditions for the preparation of SLP loaded carbonate particles were as followed:2% sodium caseinate,the ratio of water to oil 8:1,stirring at 1600 r/min for 80 s. The calcium loading efficiency was up to 99.8%. The Carr mobility index of the chewable tablet with premix of SLP loaded calcium carbonate was higher than the common calcium carbonate. The mean tensile strength of the tablets was 210.6 N/cm² for SLP loaded calcium carbonate,while 33.5 N/cm² for common calcium carbonates. The use of SLP for calcium carbonate embedding improves the organoleptic and mechanical properties of calcium carbonate,it would have a good application prospect.