Protective Effects of Chinese Wild Blueberry Total Anthocyanins on Chronic Liver Injury Induced by Cadmium Chloride

Objective:To study the protective effects of Chinese wild blueberry total anthocyanins on chronic liver injury induced by cadmium chloride. Methods:Fifty experimental mice were randomly divided into 5 groups:Control group,CdCl₂ group,chinese wild blueberry total anthocyanins low,medium and high dose groups.All of the mice except the control group were gavaged with 1.0 mg/kg/d CdCl₂ solution to modeling. The mice from chinese wild blueberry total anthocyanins low,medium and high dose groups were gavaged with 10.0,20.0,40.0 mg/kg/d of Chinese wild blueberry total anthocyanins respectively,and the blank control group was gavaged the same volume of normal saline. After ninety days,observe the growth of the mice and mensurated the liver content of Cd²⁺,total antioxidant capacity(T-AOC),liver malonaldehyde(MDA)content,glutathione-s transferase(GST)content,glutathione(GSH)content,and alanine transaminase(ALT)content,aspartate transaminase(AST)content of serum. Results:Chinese wild blueberry total anthocyanins could reduce the liver Cd²⁺ content,GST content,GSH content extreme significantly(p<0.01),reduce MDA content of serum significantly(p<0.05)and increase liver T-AOC,GST content,GSH content significantly compared with CdCl₂ group(p<0.05). Conclusion:Chinese wild blueberry total anthocyanins could protect the chronic liver injury induced by CdCl₂.