Effect of Total Organic Acids from Armeniaca sibirica L. on Antihyperlipidemia in Hyperlipidemia Rats

Objective:The effects of total organic acids from Armeniaca sibirica L.(TOAAS)on serum lipid level and antioxidant Index in hypertensive rats was studied over time.Methods:180 experimental rats were fed with high-fat emulsion(male and female half),and were randomly divided into three cycle groups(20,40 and 60 d).Each cycle group was randomly divided into six groups(blank control group,hyperlipidemia model group,Xuezhikang positive control group,and Armeniaca sibirica L. organic acid high,medium and low dose groups).Gavage continuously and blood was taken from the heart on 20, 40 and 60 d,respectively,and then,prepare serum.The effects of TOAAS on serum lipid levels and antioxidant index in 20,40 and 60 d experimental rats were detected by kit. Results:TOAAS significantly(p<0.01)reduced serum lipid levels in hyperlipidemia rats:triglyceride(TG),total cholesterol(TCH),low density lipoprotein cholesterol(LDL-C),and significantly(p<0.01)improved the high-density lipoprotein cholesterol(HDL-C)content,There was no dose-dependent,but a certain time-dependent;TOAAS could increase the activity of lipase(LPS),total lipase(LPL+HL),but there was no dose-time dependence;TOAAS could significantly(p<0.01)enhance the activity of superoxide dismutase(SOD)and glutathione peroxidase(GSH-PX)and decrease(p<0.05)the serum MDA content with dose and time-dependent.Conclusion:TOAAS could reduce serum lipid possibly by reducing serum lipidblood fat levels in hyperlipidemia rats,increase HDL-C concentration and enhance the activity of the body antioxidant enzymes decomposition of triglyceride enzymes.