Effects of ferrous threonine chelate on improving the iron status of iron-deficiency anemia rats

Objective:The effects of ferrous threonine chelate(Thr-Fe)on improving the iron status of rats suffering iron deficiency anemia(IDA)were investigated. Method:The IDA model of male weaning SD rats was established by iron-deficiency diet. And IDA rats were randomly divided into three Thr-Fe dose groups,positive control group,low-Fe control group,basing on their hemoglobin contents and body weights. A blank control group was set up,in addition. There were 6 rats in each group. The 8,16,32 mg/kg·bw of Thr-Fe were orally administered to the three Thr-Fe dose groups once a day,respectively,lasting 21 days uninterruptedly;32 mg/kg·bw of ferrous sulfate was given to positive control group in the same way. Results:After recovery test,the blood indexes such as hemoglobin and serum ferritin of IDA rats and the body weights in Thr-Fe high dose groups were improved and significantly higher(p<0.01)than those in low-Fe control group,while the transferrin(p<0.01)and total iron binding capacity(p<0.05)were significantly lower,and the free erythrocyte protephyrin of the three Thr-Fe dose groups were significantly lower(p<0.01). The indexes of IDA rats in high dose group of Thr-Fe were better than that in positive control group. Conclusion:Supplements of Thr-Fe could improve the iron status of IDA rats,increasing the contents of functional iron and iron storage,promoting iron transportation. Effects of Thr-Fe on body weights and hemoglobin of IDA rats are dose-dependent and the effects of Thr-Fe on iron status of IDA rats are better than that of ferrous sulfate.