Structural identification of curcumin/β-cyclodextrin polymer inclusion complex and its antioxidant activity

In this study, curcumin/β-cyclodextrin polymer inclusion complex were prepared by β-cyclodextrin polymer materials and its antioxidant activity was also studied. The content of curcumin in inclusion complex was detected by HPLC method and the structure of inclusion complex was identified by differential scanning calorimetry ( DSC) , X-ray diffractometry ( XRD) and Fourier transform infrared spectroscopy ( FT-IR) .Moreover, the spectrophotometric method was used to investigate the ability of inclusion complex to scavenge 2, 2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid ( ABTS) and 1, 1-diphenyl-2-picrylhydrazyl ( DPPH) radicals.The experimental results showed that the yield and the encapsulation efficiency of inclusion complex was 63.5% and 34.5%, respectively. The formation of inclusion complex was proved by DSC, FT-IR, and XRD.Antioxidant activity assay analysis showed that inclusion complex exhibited strong scavenging effects on ABTS and DPPH free radicals in a dose-and time-dependent manner. The results demonstrated that inclusion complex with certain antioxidant activity could be obtained using the method reported in this paper, which provided the new technology method and theory reference data for the formulation improvement and application of curcumin.