LI Pei-xu. Study on synthesis of roxithromycin molecularly imprinted adsorption resin and its adsorption properties[J]. Science and Technology of Food Industry, 2017, (19): 74-78. DOI: 10.13386/j.issn1002-0306.2017.19.014
Citation: LI Pei-xu. Study on synthesis of roxithromycin molecularly imprinted adsorption resin and its adsorption properties[J]. Science and Technology of Food Industry, 2017, (19): 74-78. DOI: 10.13386/j.issn1002-0306.2017.19.014

Study on synthesis of roxithromycin molecularly imprinted adsorption resin and its adsorption properties

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  • Received Date: March 07, 2017
  • In this paper, roxithromycin ( ROX) molecularly imprinted macroporous D101 resin ( ROX-MIP-D101) was synthesized by free-radical solution polymerization process with ROX as template molecule, acrylamide as the functional monomer, ethylene glycol dimethacrylate as crosslinker, 2, 2-azobisisobutyronitrile as initiator, and D101 resin as carrier. And the structure was characterized by infrared spectroscopy ( IR) and scanning electron microscope ( SEM) . The adsorption properties of ROX-MIP-D101 on roxithromycin were studied by static binding experiment and dynamic binding test, and its selective adsorption properties was investigated by selective adsorption test with erythromycin as the competing substrate.Results showed that the equilibrium adsorption capacity of ROX-MIP-D101 on ROX was 253 mg/g which was obviously higher than that of NIP-D101 ( 211 mg/g) , showing that the adsorption capacity of ROX-MIP-D101 was better than that of NIP-D101.The separation factor of ROX-MIP-D101 on ROX and EM was 1.26, showing that ROX-MIP-D101 displayed high recognition ability to ROX.The separation factor of NIP-D101 on ROX and EM was 1.01, showing no recognition ability to ROX.ROX-MIP-D101 also exhibited a good regenerability and reusability. The average recovery of water spiked with ROX standard was90.8%.
  • [1]
    李周敏, 孙艳艳, 姚开安, 等.动物源性食品中抗生素残留检测前处理及其分析方法研究进展[J].药物分析杂志, 2013, 33 (6) :901-906.
    [2]
    Ronald AY, John P G, Eugene M S.Roxitliromycin, a review of antibacterial activity.Pharmacokinetics properties and clinical efficacy[J].Drugs, 1989, 37 (1) :2-4.
    [3]
    Zhang H, Wang S.Review on enzyme-linked immunosorbent assays for sulfonamide residues in edible animal products[J].J.Immunol Methods, 2009, 350:1-8.
    [4]
    刘佳佳, 金芬, 佘永新, 等.液相色谱-串联质谱法测定牛奶中5种多肽类抗生素[J].分析化学, 2011, 39 (5) :652-656.
    [5]
    刘佳佳, 佘永新, 刘洪斌, 等.高效液相色谱-串联质谱法同时测定动物源性食品中24种磺胺类药物残留[J].分析实验室, 2011, 30 (2) :9-15.
    [6]
    陈辉华, 戴军, 王洪新, 等.HPLC法对鱼肉中3种四环素类和5种氟喹诺酮类兽药残留的同时测定[J].分析测试学报, 2008, 27 (9) :951-956.
    [7]
    薄海波, 雒丽丽, 曹彦忠, 等.超高效液相色谱-串联质谱法测定牛奶中6种聚醚类抗生素残留量[J].分析化学, 2009, 37 (8) :1161-1165.
    [8]
    耿志明, 李鹏, 陈明, 等.基质固相分散-高效液相色谱法测定鱼肉中磺胺类药物残留[J].江苏农业学报, 2006, 22 (3) :310-317.
    [9]
    王学翠, 刘冰, 张璐鑫, 等.多壁碳纳米管基质固相分散-高效液相色谱测定牛奶中6种四环素[J].食品科学, 2011, 31 (14) :206-212.
    [10]
    Pensabene J W, Fiddler W, Donoghue D J.Isolation of chlorampheni-col from whole eggs by supercritical fluid extration with in line collection[J].J.AOAC Int, 1999, 82 (6) :1334-1342.
    [11]
    Martin D, Michael K O, Jeremy G D.Development and optimisation of a method for the extraction of benzimidazoles from milk using supercritical carbon dioxide[J].Anal Chim Acta, 2003, 483:313-323.
    [12]
    Chapuis F, Mullot J U, Pichon V G, et al.Molecularly imprinted polymers for the clean-up of a basic drug from environmental and biological samples[J].Chromatogr A, 2006, 1135 (2) :127-134.
    [13]
    Arimn M, Miller E I, Cormaek P.Molecularly imprinted solid-phase extraction of iazepam and its metabolites from samples[J].Anal Chem, 2007, 79 (1) :256-262.
    [14]
    唐志民, 马新宾.邻苯二甲酸二辛酯印迹吸附树脂的制备及其吸附性能[J].化工进展, 2016, 35 (7) :2135-2139.
    [15]
    唐志民, 马新宾.林可霉素分子印迹材料的制备及吸附性能[J].中国粉体技术, 2016, 22 (5) :63-67.
    [16]
    贾宝秀, 孙晓业, 李玉琴, 等.罗红霉素分子印迹聚合物的合成及其特性研究[J].中国现代应用药学, 2010, 27 (5) :441-444.
    [17]
    唐志民, 马新宾.硅胶表面罗红霉素分子印迹聚合物的制备及选择性吸附性能[J].化工进展, 2016, 35 (4) :1162-1166.
    [18]
    张敏波, 张琪霞, 金耀楚.罗红霉素片溶出度的分光光度测定[J].中国医药工业杂志, 1996, 27 (6) :260-262.
    [19]
    于慧娟, 蔡友琼, 顾润润.高效液相色谱法测定红霉素、甲红霉素和罗红霉素的研究[J].分析实验室, 2006, 25 (6) :63-66.
    [20]
    Chen R R, Qin L, Jia M, et al.Membrane fouling in membrane bioreactors characterisation, con-tradictions, cause and cures[J].J Membr Sci, 2010, 363:212-220.
    [21]
    Beres S P, Huang Y B, Oral E, et al.Surface modifieations and molecular of polymers in medical and pharmaeeutieal applicat imprinting ions[J].J Controlled Release, 2001, 72 (1/2/3) :25-33.
    [22]
    王茹娟, 马应霞, 路翠萍, 等.谷胱甘肽磁性分子印迹聚合物的制备及吸附性能研究[J].化学学报, 2014, 72 (5) :577-582.
    [23]
    Kang Y F, Duan UAN W P, Li Y, et al.Molecularly imprinted polymers of allyl-p-cyclodextrin and methacrylic acid for the solid-phase extraction of phthalate[J].Carbohydrate Polymers, 2012, 88 (2) :459-464.
    [24]
    戈延茹, 曹恒杰, 傅海珍, 等.溶剂浮选分离-紫外光谱测定环境水样中的罗红霉素残留量[J].理化检验化学分册, 2011, 47:653-658.
    [25]
    吴晶.林可霉素分子印迹聚合物合成、表征及应用的研究[D].合肥:安徽农业大学, 2013.
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