Influences of PI factor structural analogues on the production of natamycin from Streptomyces Chattanovgensis

Preliminary screening was carried out to obtain PI factor structural analogues that can effectively induce natamycin production in the fermentation culture by Streptomyces Chattanovgensis.Box-Behnken experimental design was adopted to build regression model between single factor and natamycin production, according the response surface analysis to determine the optimal conditions. The results indicated that 1, 2-propanediol, glycerol and triethanolamine effectively increased natamycin production.With volume of 0.42, 0.43 and 1 m L for these PI factor structural analogues in 50 m L culture under the condition of120 h, the yield of natamycin was 2.5 g/L, which was 0.60 times higher than that of the control group.It can be seen that a certain amount of PI factor structural analogues can increase the yield of natamycin.