Study on the conversion process of sucralose-6-acetate to sucralose in methanol and recrystallized process improvement

Sucralose was obtained from sucralose-6-acetate under the conditions of alkaline content of sucralose as index, investigated the effects of reaction temperature, p H and reaction time on deacetylation by mixed-level uniform design. Data processing software ( DPS) was used to obtain the result that the average yield of sucralose was 79.49% at the reaction temperature 35.0 ℃, adjusted to p H = 10.0 and reaction time 2.3 h. The absolute deviation relative to model-calculated theoretical value was 1.26%.These results showed the feasibility for design the conversion process of sucralose-6-acetate and obtained the optimal conditions of the alcoholysis by DPS.In the recrystallization purification process, the ethyl acetate and butyl acetate were used as extracting agent, the organic phase was washed several times by distilled water and then the water phase was collected.Then the TGS product was obtained by the proceture of actived carbon decoloration, filtration, ultrasonic, cooling, recrystallization, drying and other processes. Analyzed by IR and HPLC, the highest purity of TGS was up to 99.23% and the water content was less than 1.0%. It had provided a feasible method for sucralose industrialized production and crystallization purification technology.