Fermentation process of Candida utilis for selenium- enriched and production of glutathione

XIANG Si-wen; ZHENG Lei; ZHU Long-bao; GE Fei; TAO Yu-gui; DU Guo-cheng

doi:10.13386/j.issn1002-0306.2017.01.024

XIANG Si-wen, ZHENG Lei, ZHU Long-bao, GE Fei, TAO Yu-gui, DU Guo-cheng. Fermentation process of Candida utilis for selenium- enriched and production of glutathione[J]. Science and Technology of Food Industry, 2017, (01): 165-168. DOI: 10.13386/j.issn1002-0306.2017.01.024

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Fermentation process of Candida utilis for selenium- enriched and production of glutathione

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The main purpose of this study was to prepare high bioactive selenium/glutathione-enriched yeast,the Candida utilis was used as the parent strain.The culture process and selenite addition mode were investigated in a 100 L stirred fermentor.The result showed that exponential feeding was the most suitable approach to attain high concentrations of cell(72 g/L),intracellular GSH(1080 mg/L) and selenium organic transformation rate( 86%) with feeding of 125 mg/L Na_2SeO_3 and3 mmol / L L-cys,the intracellular selenium reached 1493 μg/g.

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Science and Technology of Food Industry

Fermentation process of Candida utilis for selenium- enriched and production of glutathione

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