Effects of Haematococcus pluvialis astaxanthin on diabetes mice for decreasing blood glucose and its mechanisms

To explore effect of Haematococcus pluvialis astaxanthin to mice diabete for decreasing blood glucose and its mechanisms. Experimental diabete mice was induced by alloxan( ALX)( 45 ~ 50 mg / kg BW iv). With25 mg / kg and 100 mg / kg dose of Haematococcus pluvialis astaxanthin( 2%) for 14 d lavage alloxan diabete mice,the blood samples of mice were collected by orbit,blood glucose,insulin,SOD,GSH- Px activity and MDA level in the blood were measured.The liver and kidney were taken to weigh,SOD,GSH- Px activity and MDA level in the tissues were measured.The results showed that Haematococcus pluvialis astaxanthin could significantly( p < 0.05)inhibit diabete mice weight of reduction and return to normal,reduce( p < 0.01) water intake and diet intake and reduce( p < 0.01) high blood glucose levels of diabete mice and improve the ability of antioxidation,the mechanism of ASX in reducing blood glucose might be achieved by regulating the insulin.