Study of Cir Q- Life suga balanz capsule on decreasing levels of blood glucose,serum lipid and acute toxicity

Objective: To observe the assistant effects of Cir Q- Life suga balanz( CSB) capsules on decreasing the levels of blood glucose and serum lipid in type 2 diabetes mellitus( T2DM) rats and acute toxicity in mice.Methods:T2DM models were built with the method of higher lipid and sugar diets and injection of a low dose of streptozotocin.Rats were divided into normal group,model group and the low,middle,high dose( 75,150,300 mg · kg- 1·BW) of CSB capsules groups.Three dose groups rats were administrated with CSB capsules per day for 5 weeks.The fasting blood glucose( FBG),serum lipid,serum insulin( INS) were tested. The acute toxicity of CSB capsules was investigated by the maximum toxicity dose( MTD) method. Result: Compared with model group,the FBG in high dose of CSB capsules group was decreased significantly( p < 0.05),and the glucose tolerance presents showed certain changes,but the difference was not statistically significant.The serum INS levels and serum cholesterol( TC) levels did not significantly change,but the serum triglyceride( TG) was reduced obviously( p < 0.05) in three dose of CSB capsules groups compared to the model group. The daily MTD of CSB capsules in mice was26.0 g / kg·BW which was innocuous substance.Conclusion: CSB capsules has assistant effects for decreasing levels of FBG and TG in T2 DM rats.