Risk assessment for the sodium 2-( 4- methyoxy- phenoxy)propanoate in high sugar food

To investigate the safety of chemical synthesized aryloxycarboxylic acid- sodium 2-( 4- methyoxy-phenoxy) propanoate( CPMP) in food manufacture as food additive,the toxicological evaluation of CPMP was studied by employing animal tests and the utilization investigation was preceded using high performance liquid chromatography.The toxicological results indicated that the LD₅₀ of CPMP was 6577 mg / kg bw,and the Ames test and the mice sperm abnormality test were separately demonstrated that the CPMP had no significant mutagenicity and genetic toxicity. The detection results of HPLC showed that CPMP was applied frequently in mooncakes,candies and pastries,the average additive quantities were 149.48 ± 1.26,52.30 ± 1.87,71.31 ± 1.39 mg / kg,respectively,the median additive quantities were 118.05 ± 2.11,72.58 ± 0.94,65.77 ± 1.02 mg / kg,respectively; the95% additive quantities were 439.97 ± 2.06,340.77 ± 1.45,137.63 ± 1.62 mg / kg,respectively. The risk assessment of CPMP result suggested that CPMP may influence on the safety of high sugar foods when the additive amount of CPMP was more than the 95% additive amount attributed to exposed quantity beyond the ADI.