Optimization of formulation and preparation process for glutamate chelating calcium tablets

The preparation process of glutamate chelating calcium tablets were studied,and egg shells was taken as material.In the experiment,tablets were made by pressing powder directly. On the basis of the single factor experiments,the preparation process of glutamate chelating calcium tablets was optimized using Box- Behnken.The amounts of glutamate chelating calcium,microcrystalline cellulose,hydroxypropyl methylcellulose and microsilica were taken as response factors,composite indicator as response surface value.The results showed that the optimal addition of main material and accessories were as follows: glutamate chelating calcium 40.57%,microcrystalline cellulose 40.88%, hydroxypropyl methylcellulose 20.16%, micro- silica 1.54% and the comprehensive score of the tablets was 9.99,which was in good agreement with the predict value of 10.00. The glutamate chelating calcium tablets made with optimum formula were characterized by smooth surface,uniform colour and lustre,good molding ability,good solubility,which didn't only save the cost of raw materials for the amino acid chelate calcium tablets,but also provided reference for the development of calcium preparations.