Effect of Lactobacillus plantarum SCS1 on blood glucose levels in hyperglycemia model mice

The effect on body weight and blood glucose levels in hyperglycemia model mice by administrating Lactobacillus plantarum SCS1(L. plantarum SCS1) was researched in the study.Meanwhile,glucose tolerance,content of K~+,Na+and Cl~- in plasma and content of glycogen were also studied. Sixty 3-week-old male KM mice in a SPF grade were divided into six groups randomly,including NG,MG,PG,TGL,TGM and TGH. NG mice were fed with MRS medium( 10 m L / kg body weight). PG mice were fed with concentration of 6. 0 ×109CFU/m L L. plantarum SCS1 suspensions from the second week to third week. MG mice were fed with sterile physiological saline(10 m L/kg body weight). TGL,TGM and TGH mice were fed with concentration of2.0×10~9,4.0×10~9and 6.0×10~9CFU/m L L. plantarum SCS1 suspensions(10 m L/kg body weight) respectively from the fourth week to the end of the experiments. The hyperglycaemia model were established with 1-week high diet plus with 70 mg/kg of STZ injection. The results showed that the blood glucose of TGH mice were reduced by high dose(6.0 ×10~9CFU/m L) fermentation broth of L. plantarum SCS1 significantly(p <0.05)compared with mice,and the preventive effect was not significant. Otherwise,the glucose tolerance of TGHmice were decreased by fermentation broth of L. plantarum SCS1 significantly(p<0.05),content of K~+ in plsma of TGH mice were increased,content of Na+and Cl~- in plasma and glycogen were decreased by fermentation broth of L. plantarum SCS1 significantly( p < 0. 05) compared with MG mice. These results suggested that L. plantarum SCS1 fermentation broth showed a hypoglycemic effect on hyperglycaemia model mice. Loss of K~+,increased Na+,Cl-in plasam and glycogen caused by hyperglycaemia were improved by L. plantarum SCS1 fermentation broth.