TAN Ming-liang, CHEN Gang. Study on effect and mechanism of tea polyphenols on serum uric acid in hyperuricemic mice[J]. Science and Technology of Food Industry, 2015, (12): 349-352. DOI: 10.13386/j.issn1002-0306.2015.12.066
Citation: TAN Ming-liang, CHEN Gang. Study on effect and mechanism of tea polyphenols on serum uric acid in hyperuricemic mice[J]. Science and Technology of Food Industry, 2015, (12): 349-352. DOI: 10.13386/j.issn1002-0306.2015.12.066

Study on effect and mechanism of tea polyphenols on serum uric acid in hyperuricemic mice

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  • Received Date: September 26, 2014
  • To explore the effect of tea polyphenols on hyperuricemia (HUA) in mice and its potential mechanism, HUA was induced by intragastric administration of potassium oxonate in mice. HUA mice were treated with150, 300 and 600mg/kg tea polyphenols for 7 days. Uric acid level in serum was tested by phosphotungstic acid assay. Xanthine oxidase activity in serum and liver was determined by chemical colorimetric assay.Results showed that after treatment with 300 and 600mg/kg tea polyphenols, serum level of uric acid markedly reduced by approximate 22% and 29% (both p<0.01) compared with that of model group. Meanwhile, xanthine oxidase activity in serum markedly decreased by approximate 14% (p<0.05) and 21% (p<0.01) , as well as the liver xanthine oxidase activity markedly decreased 16% (p <0.05) and 21% (p <0.01) . In conclusion, tea polyphenols might reduce the level of uric acid in hyperuricemic mice, and the hypouricemic effect of tea polyphenols might be closely associated with the inhibition of xanthine oxidase activity.
  • [1]
    臧路平, 刘志刚, 吴新荣.高尿酸血症发病机制及其药物治疗研究进展[J].医药导报, 2011, 30 (1) :69-73.
    [2]
    李东晓, 迟家敏.高尿酸血症与代谢综合征[J].国外医学·内分泌学分册, 2004 (6) :386-388.
    [3]
    牛艳芬, 朱华结, 马加, 等.黄嘌呤氧化酶抑制剂的筛选及P40的降尿酸作用研究[J].中药药理与临床, 2011, 27 (11) :18-20.
    [4]
    王春辉, 李松.黄嘌呤氧化酶抑制剂的研究进展[J].国外医学药学分册, 2006, 33 (5) :351-353, 357.
    [5]
    Wang YY, Yang XR, Li KK, et al.Simultaneous determination of theanine, gallic acid, purine alkaloids, catechins, and theaflavins in black tea using HPLC[J].International Journal of Food Science and Technology, 2010 (45) :1263-1269.
    [6]
    朱桂勤, 李建科.茶多酚的功能研究进展[J].食品研究与开发, 2005, 26 (1) :33-35.
    [7]
    倪静, 孙慧.茶多酚的研究进展[J].中国药物经济学, 2013 (S3) :40-41.
    [8]
    Chen YS, Hu QH, Zhang X, et al.Beneficial effect of rutin on oxonate-induced hyperuricemia and renal dysfunction in mice[J].Pharmacology, 2013 (92) :75-83.
    [9]
    Yan HY, Ma Y, Liu M, et al.The dual actions of Paederia scandens extract as a hypouricemic agent:xanthine oxidase inhibitory activity and uricosuric effect[J].Planta Med, 2008 (74) :1345-1350.
    [10]
    叶瑛, 贾楠.高尿酸血症-心血管事件的独立危险因素[J].国际心血管病杂志, 2010, 37 (4) :229-231.
    [11]
    刘佳, 李玲.高尿酸血症的发病机制与药物治疗研究进展[J].国际药学研究杂志, 2010, 37 (1) :24-28
    [12]
    赵莹, 张启虹, 冯明声, 等.降尿酸药物黄嘌呤氧化酶抑制剂的研究进展[J].药学进展, 2009, 33 (2) :55-61.
    [13]
    Macedo JA, Battestin V, Riberiro ML, et al.Increasing the antioxidant power of tea extracts by biotransformation of polyphenols[J].Food Chemistry, 2011 (126) :491-497.
    [14]
    全吉淑, 尹学哲, 金泽武, 道.茶多酚自由基清除及抗脂蛋白氧化作用研究[J].中药药理与临床, 2007, 23 (3) :75-77.
    [15]
    王莹.茶多酚的抗氧化和抑菌活性及其增效剂[J].生物学杂志, 2007, 24 (5) :54-56.
    [16]
    Peng HQ, Cai WM, Xiang X, et al.The anti-influenzavirus A3 action in vitro of tea polyphenols[J].J Tea Sci, 2003, 23 (1) :79-81.
    [17]
    Nagao T, Hase T, Tokimitsu I.A green tea extract high in catechins reduces body fat and cardiovascular risks in humans[J].Obesity (Silver Spring) , 2007, 15 (6) :1473-1483.
    [18]
    Mc Larty J, Bigelow RL, Smith M, et al.Tea polyphenols decrease serum levels of prostate-specific antigen, hepatocyte growth factor, and vascular endothelial growth factor in prostate cancer patients and inhibit production of hepatocyte growth factor and vascular endothelial growth factor in vitro[J].Cancer Prev Res (Phila Pa) , 2009, 2 (7) :673-682.
    [19]
    杨贤强, 贾之慎, 沈生荣, 等.茶多酚类毒理学实验及其评价[J].浙江农业大学学报, 1992, 18 (1) :23-29.
    [20]
    孔悦, 张冰, 刘小青, 等.黄嘌呤氧化酶活性在高尿酸血症动物模型中的变化[J].北京中医药大学学报, 2004, 27 (6) :38-41.
    [21]
    Hou CW, Lee YC, Hung HF, et al.Longan seed extract reduces hyperuricemia via modulating urate transporters and suppressing xanthine oxidase activity[J].Am J Chin Med, 2012, 40 (5) :979-991.
    [22]
    蔡泳, 陈雪观.别嘌醇致严重不良反应分析[J].医药导报, 2012, 31 (2) :264-266.
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