Effect of grape seed extract on endogenous metabolites in human urine
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Abstract
Objective:To investigate the changes of endogenous metabolites in Human urine after administration of grape seed extract (GSE) via NMR-based metabolomics. Methods :Sixteen healthy male students were randomly and averagely divided into two groups (A and B) . The volunteers in the group (A) were administrated2 GSE capsules per day for 14 days, while those in the group (B) were given the Placebo capsules only. Urine samples were collected at 0th and after administration of grape seed extract (14th) individually. The urine samples were analyzed with technique of1H-NMR and pattern recognition. Results :Compared with the Placebo-treated group, the levels of lactate decreased and the levels creatinine increased significantly in the GSE-treated group (p<0.05, 0.01) . The level of lactate, creatin, taurine in GSE-treated group were lower than the placebo-treated group with significant difference (p<0.05) . Conclusion:As one of good nutrition supplements for sports, administration of GSE heavily regulated the endogenous metabolites, which involved with the energy metabolism and amino acid metabolism. The application of1H-NMR metabolomics technology in sports science will be in spread in the future.
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