Optimization of the preparation process of resveratrol β cyclodextrin inclusion compound by response surface methodology

The aim of the experiment was to optimize the preparation process of resveratrol inclusion compound.Based on the single factor test,response surface experiment was carried out to optimize the preparation process of resveratrol inclusion compound with overall desirability of inclusion rate and yield as appraisement criteria. The formation of inclusion compound was validated utilizing differential scanning calorimetry.The result showed that the optimum preparation process of resveratrol inclusion compound was as follows: the feed ratio of β cyclodextrin and resveratrol( molar ratio) 2 ∶1,inclusion temperature 40℃,inclusion time 63 min. And the analysis result of differential scanning calorimetry indicated that resveratrol inclusion compound had formed.