Effect of ethanol accumulation on porcine interferon- α production by Pichia pastoris and activities of key enzymes in carbon metabolism

DING Jian; GAO Min-jie; HOU Guo-li; LIANG Ke-xue; SHI Zhong-ping; YU Rui-song; LI Zhen

doi:10.13386/j.issn1002-0306.2014.21.024

DING Jian, GAO Min-jie, HOU Guo-li, LIANG Ke-xue, SHI Zhong-ping, YU Rui-song, LI Zhen. Effect of ethanol accumulation on porcine interferon- α production by Pichia pastoris and activities of key enzymes in carbon metabolism[J]. Science and Technology of Food Industry, 2014, (21): 150-153. DOI: 10.13386/j.issn1002-0306.2014.21.024

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Effect of ethanol accumulation on porcine interferon- α production by Pichia pastoris and activities of key enzymes in carbon metabolism

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In the present study, taking two batches with low ethanol accumulation under 2g / L as control group, effect of long- term ( > 4h) and instantaneous high ethanol concentration ( > 10 g / L) on porcine interferon αproduction and activities of key enzymes in carbon metabolism was discussed. As a result, long- term high ethanol concentration severely deteriorated specific activities of the enzymes, and p IFN- α expression level was decreased about 4 ~ 12 folds. Similarly, instantaneous high ethanol concentration also deteriorated specific activities of the enzymes, and p IFN- α expression level was decreased about 8 folds.

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Effect of ethanol accumulation on porcine interferon- α production by Pichia pastoris and activities of key enzymes in carbon metabolism

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