Study on extraction methods and α-glucosidase inhibitory activity from the total triterpenes of Rosa roxbughii

The extraction yield of total triterpenes from R. roxbughii that was extracted by different extraction methods and the α-glucosidase inhibition activities of the best extraction of total triterpenes was studied. To investigate the extraction yield of total triterpenes to extract by five different extraction methods (water boiling and precipitation with ethanol, refluxing process, macro absorption resin, impregnation method, supercritical fluid extraction) , and to evaluate the highest extraction yield of the total triterpenes against α-glucosidase inhibition activities. The results showed that the total triterpene's extraction yield of refluxing process were higher than the other extraction methods, CoMParing with acarbose, the extractions A and B had preferable inhibition activities against α-glucosidase, and their IC50values were 75.2, 9.6, 3.4μg/mL, respectively. This method was economy, convenience and appropriate for commercial process, and the total triterpenes had preferable inhibition activities against α-glucosidase.