Effect of the non-volatile parts of Zanthoxylum essential oil on intestinal health in rats

Objective: To study the effect of each components of the non-volatile parts in zanthoxylum essential oil on intestinal health in rats.Methods: Using soybean oil as blank control, the volatile removed constituents of zanthoxylum essential oil ( RE) , numb taste compoents ( NTC) and the volatile and numb taste components removed part of zanthoxylum essential oil ( REN) which were respectivelly dissvoled into soybean oil were intragastriced other three rats groups.They were sacrificed at 28th day to assay several relevant indicators.Results: To the rats in NTC group, their cecal wall area was significantly reduced, the free ammonia were increased, but the SCFAs didn't change significantly, harmful bacteria were increased with beneficial bacteria reduced.Results in RE group kept the same change trend with the NTC group in weaker effects.After intragastric, the SCFAs, cecal wall area, free ammonia and beneficial bacteria of NTC group are increased, with pH and harmful bacteria reduced.Conclusion: RE and NTC will restrain rat intestinal fermentation, have negative effect on intestinal health, and the effect of NTC is stronger than RE's.