Optimization of ultrasound-assisted extraction of total lignans from Zanthoxylum armature DC.by response surface methodology

Objective:To optimize the ultrasound-assisted extraction technology of total lignans from Zanthoxylum armatum DC.Method:Based on the single-factor tests, the extraction conditions of ethanol concentration, ratio of solvent to material, extraction temperature and ultrasonic power were optimized by response surface methodology in order to increase the extraction rate of total lignans from Zanthoxylum armatum DC. Results:The optimal extraction rate of lignans were ethanol concentration 79.6%, ratio of solvent to material 20mL /g, extraction temperature 67.0℃ and ultrasonic power 150W.Under these optimized conditions, the extraction yield of total lignans was up to 3.406%, which was agreed with model predictions. Conclusion:The extraction process by response surface methodology was reliable and the optimal extraction rate of lignans was achieved.