Study on optimization of the extraction of total flavonoids from date seeds by response surface methodology

The experiment is carried to achieve the optimal conditions for ultrasonic extraction of total flavonoids from Chinese date seeds.Base on single-factor experiments, the extraction conditions of the total extraction yield of flavonoids in the date seeds were optimized by response surface analysis method.The results showed that optimum extraction process conditions were as follows:solid-liquid ratio 1 ∶50, ultrasonic power 305W, extraction temperature 60℃.The result of verification experiment (7.03mg/g) was coincided with predictive value.The extraction ratio of total flavonoids was effectively improved with the optimum extraction conditions, which could provide a reference for the reuse of date seeds.