Study on the anti-mutagenic effect of Cordyceps militaris polysaccharide

To evaluate the effect of Cordyceps militaris polysaccharides (CMPS) on micronucleus formation rate of polychromatic erythrocyte (PCE) of bone marrow cells in mice and chromosome aberration rates induced by cyclophosphamide (CTX) . Micronucleus test and chromosomal aberration test were carried out. The micronucleus inhibition rates were 29. 75%, 36. 20% and 44. 48% respectively in CMPS1, CMPS2 and CMPS3 group. Inhibition rates were increased with the dose increasing. Compared with the CTX group, each dose group were significantly different (p<0. 05) . The aberration rates which were decreased with the dose increasing were 36. 7%±5. 46%, 20. 8%±3. 52% and 18. 1%±3. 28% respectively in CMPS1, CMPS2 and CMPS3 group. CMPS could reduce the micronucleus inhibition rates of PCE of bone marrow cells in mice and the aberration rates induced by CTX, CMPS had anti-mutagenic activity.