Effect of Chicory Root extract on blood lipid in hyperlipemia hamsters

To investigate the effect of chicory root extract on lowering blood lipid.The male hamsters were divided into 6 groups, including the normal group, the model group, intervention groups administered with water extract and alcohol extract of chicory root at doses of 1.0% and 5.0%.Hyperlipidemic indicators were tested after collecting serum samples.Results:Compared with the model group, the concentration of total cholesterol (TC) , triglyceride (TG) and non-high density lipoprotein cholesterol (non-HDL-C) in serum exhibited a significant decrease in serum from the low-dose and high-dose group of water extract and alcohol extract of chicory root (p<0.01) .The concentration of high density lipoprotein cholesterol (HDL-C) in serum exhibited a significant increase and a increase from high-dose group of water extract and high-dose group of alcohol extract (p<0.01) , (p<0.05) .The content of MDA was decreased in serum and liver in the low-dose and high-dose group of water extract and the high-dose group of alcohol extract.Conclusion:Water extract and alcohol extract of chicory root had an obvious effect on lowering blood lipid and inhibiting lipid peroxidation in hyperlipemia hamsters.The effect of lowering total cholesterol (TC) and triglyceride (TG) with alcohol extract was better than water extract.On the other hand, the effect of heightening high density lipoprotein cholesterol (HDL-C) with water extract was more obvious than alcohol extract.