Structure identification of inclusion complex of Florfenicol with β-cyclodextrin

Objective:To prepare and identify the inclusion complex of florfenicol with β-cyclodextrin.Methods:The inclusion complex was obtained by the ultrasonic method, the preparation conditions were as follows:ratio of Florfenicol and β-cyclodextrin was 1:1 (mol/mol) , ultrasound temperature was 60℃, ultrasound time for 5h, and identified the structure of inclusion complex by the methods of Fourier infrared spectrum (FIIR) and X-ray powder diffractometry (XRD) .Results:The yield of inclusion complex was 93.52% and the inclusion ratio of inclusion complex was 38.09% under these conditions.At the same time, the formation of inclusion complex was proofed by FIIR and XRD.Conclusion:This technology had good yield and the Florfenicol-β-cyclodextrin inclusion complex exhibited some new physical characteristic.