Anti-tumor effect of ethanol extracts from Fomitopsis officinalis (Vill.:Fr.) Bond.in vitro

The anti-tumor effect of ethanol extracts from Fomitopsis officinalis (Vill.:Fr.) Bond.on various human tumor cell lines in vitro was evaluated.The sulforhodamine B (SRB) assay was employed to evaluate the anti-tumor effect of ethanol extracts from Fomitopsis officinalis (Vill.:Fr.) Bond.on BEL-7404, H-1299 and SGC-7901 cells in vitro.The results showed that ethanol extracts displayed obvious inhibitory effect on the proliferation of BEL-7404 and SGC-7901 in a dose-dependent manner, while their inhibitory effect on H-1299 was not evident.The IC50 value of BEL-7404 and SGC-7901 were 73.5μg·mL-1 and 80μg·mL-1 respectively.The cell cycle of BEL-7404 treated by ethanol extracts changed.The ratio of cultured cell declined in G2/M phase, while the cell in S phase increased.The cell cycle arrested in S phase.Ethanol extracts from Fomitopsis officinalis (Vill.:Fr.) Bond.had relatively obvious anti-tumor effect in vitro.