Abstract: Parkinson's disease (PD) is a neurodegenerative disease influenced by genetic and environmental factors, and its pathogenesis is still unclear. Compared with healthy people, the intestinal flora of patients with PD is disturbed, which is manifested by an increase in the abundance of intestinal microbial and an increase in specific bacteria. Probiotics can effectively improve the quality of PD patients' life by regulating the intestinal flora and improving symptoms such as inflammation, constipation and abdominal pain. Based on these properties, probiotics are expected to become an adjunct to the treatment of Parkinson's disease in real life. Starting from the aspects of intestinal flora, disease course and treatment methods of Parkinson's patients, this paper reviews the research reports in recent years. Moreover, this paper summarizes the characteristics of intestinal flora of Parkinson's patients and the relationship between them, and discusses the new therapeutic methods of probiotic intervention, which provides a new reference for the treatment of Parkinson's disease.