Abstract: c-Jun N-terminal kinase (c-Jun N-terminal kinase, JNK) is a member of the mitogen-activated protein kinase (mitogen-activated protein kinase, MAPK) family. This signal transduction pathway is regulated by a series of kinases and participates in the regulation of physiological functions such as cell proliferation, differentiation, apoptosis, neuronal function and stress response, and mediates the occurrence of many diseases. Flavonoids in plant diets have the ability to resist oxidation, anti-inflammatory, and regulate vascular penetration, and can produce significant intervention effects on JNK-related diseases by regulating oxidative stress. This article introduces the research progress of plant flavonoids intervening oxidative stress-related diseases by regulating the JNK pathway, and provides reference for future research and application.