Abstract: Vibrio parahaemolyticus is a causative agent of human serious seafood-borne gastroenteritis disease and even death. It is the first risk factor of food safety issues in China,particular in the littoral provinces. The bacterium infected host by secreting extracellular proteins and virulence factors into the extracellular environment or directly into the host target cells. In this paper,the virulence factors and secreted proteins in V. parahaemolyticus and their progress are described,and the research direction of secreted protein in the future is also discussed.