Abstract: Edible mushrooms in the market were investigated to study the arsenic contamination,and health risks of human exposure to arsenic in edible mushrooms were evaluated. Separation and determination of six arsenic species in edible mushrooms was performed by high-performance liquid chromatography-inductively coupled plasma-mass spectrometry(HPLC-ICP-MS).Safe consumption level(SCL)and safe intake(SIR)of edible mushrooms were calculated based on non-carcinogenic risk and cancer risk thresholds using the US Environmental Protection Agency(USEPA)health risk assessment model. In this batch of samples,the total arsenic content in fresh edible mushrooms and dried edible mushrooms was 0.0013~0.1240 mg/kg(on fresh weight basis)and 0.0170~3.8488 mg/kg(on dry weight basis),respectively. The total arsenic contents was not exceed the limit of total arsenic specified in GB 2762-2017. There were differences in the main arsenic species existed in different edible mushrooms. The safe consumption level of fresh edible mushrooms and dried edible mushrooms were 5.33~104.38 g/(d·BW kg)(fresh weight basis)and 0.06~5.28 g/(d·BW kg)(dry weight basis),respectively. Except for dried Agaricus blazei Murill,the safe consumption of other edible mushrooms and their products in this batch was higher than the actual consumption of edible bacteria per capita,and there was no risk of non-carcinogenicity and cancer risk to the human body.