Abstract: Objective:To study the effect of Ganoderma lucidum spores and propolis complex on immune function in mice. Methods:The female kunming mice were randomly divided into blank control, low-, medium-and high-dose groups, each group of ten. The mice were administrated with distilled water or Ganoderma lucidum spores and propolis complex for 75, 150 and 450 mg/kg bw, respectively.After 30 days, the following experiments were conducted:Body weight, immune organ index, carbon clearance ability, peritoneal macrophage phagocytosis ability, spleen lymphocyte proliferation ability, delayed-type hypersensitivity and serum hemolysin capacity. Results:Compared with the control group, peritoneal macrophage phagocytosis ability and spleen lymphocyte proliferation ability increased significantly (p<0.05) at the dose of medium and high. Serum hemolysin capacity and delayed-type hypersensitivity response and spleen lymphocyte proliferation ability increased highly significantly (p<0.01) at the dose of medium and high. Serum hemolysin capacity increased significantly at the dose of low (p<0.05).Conclusion:Ganoderma lucidum spores and propolis complex can promote the immune function in mice.