Abstract: Objective:To explore the effect of Mesona chinensis extract on blood lipld and hemorheologic parameters in rats with high fat. Methods:50 SD rats were radomly divided into 5 groups,and the rats in blank control group were fed with normal diet,and the rats in other groups were given fat diet to induce hyperlipidemia. After 8 weeks of oral administration,serum lipid levels and hemorrheologic indexes were measured. Results:Compared with the model group,the levels of total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C)were dcreased significantly(p<0.05),and highdensity lipoprotein cholesterol(HDL-C)were icreased(p<0.05)in Mesona chinensis extract groups. Meanwhile,high-middle and low-shear while blood viscosity,plasma viscosity,index of erythrocytic aggregation(IEA)were decreased significantly(p<0.05)in Mesona chinensis extract groups. The levels of super-oxide dismutase(SOD)were increased significantly(p<0.05)and the levels of malondialdehyde(MDA)were decreased significantly(p<0.05)in Mesona chinensis extract groups. The results showed that Mesona chinensis extract were not caused liver damage by detecting the glutamic-oxalacetic transaminease(GOT)and glutamic-py-ruvic transaminase(GPT). Conclusion:Mesona chinensis extract could effectively improve lipid metabolism,reduce blood lipid and improve hemorheological index.