Abstract: The extraction process of Codonopsis polysaccharide were optimized by ultrasonic water extracion and alcohol precipitation,Codonopsis polysaccharide extraction rate was used as index. A health vinegar beverage was developed by the processing of Codonopsis polysaccharide extract solution,buckwheat vinegar and honey with single factor experiments and response surface methodology(RSM). The results showed that,the optimal extraction process of Codonopsis polysaccharide were solid-liquid ratio1:30 (g/mL),ultrasonic time 60 min,ultrasonic temperature 60℃,alcohol concentration 60%,by which the extraction rate was 18.03%±0.45%. The health vinegar beverage formula results indicated that the codonopsis extract solution 100 mL,buckwheat vinegar 1 mL and honey 12 g,and the score was 84.2. The beverage by this formula had soft taste,unique flavor and each index and the quality level accorded with GB/T 30884-2014 in Chinese Tea beverages request,and this processing technology be applied in actual production.