Abstract: The effects of different drying methods on Lycium barbarum powder were explored to find the polysaccharides,flavonoids and carotenoids change of contents before and after moisture absorption. HPLC was adapted to assay the content changes of the main flavonoids and carotenoids of 3 kinds of drying methods. And the color changes before and after moisture absorption. The result showed that the contents of polysaccharides and carotenoids in the wolfberry powder were significantly decreased(p<0.05)after the same drying method. And the content of flavonoids in wolfberry powder was significantly increased(p<0.05). The content of ferulic acid,caffeic acid,the coumaric acid which in flavonoids decreased,and quercetin,rutin increased. The color parameters of L^*,a^* and b^* showed that the three kinds of dried wolfberry powder were significantly lower than those before moisture(p<0.05). The contents of polysaccharides and carotenoids in freeze-dried wolfberry powder were higher than those in the other two methods. But the flavonoid contents were the highest in hot-air-dried wolfberry powder. Its color parameters display that color differences before moisture absorption were as follows:hot-air-dried>sun-dried>freeze-dried,after moisture absorption Color differences were freeze-dried>hot-air-dried>sun-dried. Overall,the moisture absorption on the different dry way under the wolfberry powder active ingredient retention and color have a negative impact.