Abstract: objective:The study aimed to discuss the effect of konjac glucomannan on preventing drunkenness and relieving alcoholism of mice. Methods:The effect of konjac gluconannan on preventing drunkenness and relieving alcoholism of mice was explored through the methods of preventing alcoholism and relieving alcoholism and clings,and detecting the ethanol concentration in the blood of the drunken mice. Results:The konjac gluconannan could significantly(p<0.05) postpone the tolerance time of mice to the alcohol,and shorten the duration of drunkenness obviously. Depending on the results of detecting the ethanol concentration in the blood of the drunken mice,the ethanol concentration peak of the drunken mice appeared around 60 min,and the ethanol concentration of the middle and high dose KGM group was significantly(p<0.05) lower than the model group.So konjac glucomannan could decrease the ethanol concentration in the blood of the drunken mice significantly.Conclusion:The konjac gluconannan had good effects on preventing drunkenness and relieving alcoholism.