Abstract: The degradation of lignin by enzyme had a low degradation efficiency because it suffered restriction by the contact between solid state lignin and enzyme, which could be improved by combining the lightly toxic and tractable oxidant such as TiO 2 and H 2 O 2 /Fe2 +and oxidase into the process of degradation.Brousso xylem pretreatmented by TiO 2 or H 2 O 2 /Fe2 +then were degraded by photosynthesis oxidases or laccase in this paper.The results showed that papyrifera xylem fibre pretreatmented by nanometer- sized TiO 2 or H 2 O 2 /Fe2 +for 1.5h and then by photosynthesis oxidases for 1.5h, the degradation efficiency of lignin increased 36.0% or 28.8% respectively compared to those were degraded by photosynthesis oxidases for 3h alone.Conducted by nanometer- sized TiO 2 for 1.5h and then degraded by laccase for 1.5h, the degradation efficiency of lignin increased 92.4% or 85.0% compared to those were degraded by laccase for 3h.Consequently the degradation efficiency of lignin by photosynthesis oxidases or laccase could be facilitated efficiently by joint action with nanometer- sized TiO 2 or H 2 O 2 /Fe2 +.