Abstract: Objective: To explore the effect of red pigment from flowers of Cercis chinensis Bge. on blood glucose and serum lipid levels in model rats. Method: The diabetes mellitus rat model was induced with alloxan ( ALX) by abdominal cavity injecting and hyperlipidemia by intragastric administration of high-fat cream in SD rats.Animals were divided into control group and different doses groups ( high, middle and low) , and dosed according to body weight of rats. The serum glucose consistence was determined by blood glucose monitor and serum TC, TG, HDL-C and LDL-C were detected by corresponding reagent box.Results: Diabetic model rats were treated with alloxan successfully.Each dose group of red pigment from flowers of Cercis chinensis Bge. could increase body weight and middle dose, high dose all can decrease the blood glucose of diabetic rats markedly (p < 0.01) . The hyperlipoidemia model rats were treated with high-fat cream successfully. The red pigment could decrease the serum contents of TC and LDL-C significantly (p < 0.05) , middle dose and high dose could decrease the levels of TG (p < 0.05) and the value of LDL-C/HDL-C and arteriosclerotic index, high dose increase serum level of HDL-C obviously (p < 0.01) . Conclusion: The red pigment from flowers of Cercis chinensis Bge. could regulate blood glucose of diabetic rats treated with alloxan and the levels of hyperlipidemia rat treated with high-fat cream obviously.