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中国精品科技期刊2020
魏静,宋若兰,陈翔,等. 新甲基橙皮苷二氢查耳酮及合成前体药理作用研究进展[J]. 食品工业科技,2022,43(23):436−449. doi: 10.13386/j.issn1002-0306.2022010176.
引用本文: 魏静,宋若兰,陈翔,等. 新甲基橙皮苷二氢查耳酮及合成前体药理作用研究进展[J]. 食品工业科技,2022,43(23):436−449. doi: 10.13386/j.issn1002-0306.2022010176.
WEI Jing, SONG Ruolan, CHEN Xiang, et al. Research Progress on Pharmacological Activities of Neohesperidin Dihydrochalcone and Its Synthetic Precursors[J]. Science and Technology of Food Industry, 2022, 43(23): 436−449. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022010176.
Citation: WEI Jing, SONG Ruolan, CHEN Xiang, et al. Research Progress on Pharmacological Activities of Neohesperidin Dihydrochalcone and Its Synthetic Precursors[J]. Science and Technology of Food Industry, 2022, 43(23): 436−449. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022010176.

新甲基橙皮苷二氢查耳酮及合成前体药理作用研究进展

Research Progress on Pharmacological Activities of Neohesperidin Dihydrochalcone and Its Synthetic Precursors

  • 摘要: 新甲基橙皮苷二氢查耳酮(Neohesperidin dihydrochalcone,NHDC)是一种无毒、高甜度、低热量的甜味剂,具有增甜、增香、掩盖苦味、修饰风味的功能与抗氧化、抗炎、降血脂等药理活性,在食品及医药领域具有一定的开发潜力。当前NHDC的合成前体主要包括橙皮苷(Hesperidin,HSD)、新橙皮苷(Neohesperidin,NHP)和柚皮苷(Naringin,NRG),具有抗氧化、保护肝肾、抑菌和改善胃肠道等多种生物学活性。NHDC的药理研究相对具有发展进程缓慢、研究系统欠缺、机制深度缺乏等特点。本文以NHDC及其合成前体为关键词在SciFinder、Web of Science、CNKI等科学数据库中进行检索,综述了NHDC的药理作用和机制,并对其合成前体的药理研究进展进行总结,以期为NHDC的进一步综合利用和开发高附加值产品提供参考。

     

    Abstract: Neohesperidin dihydrochalcone (NHDC) is a sweetener with non-toxic, highly sweet and low-calorie characteristics. It has abilities of adding sweetness, adding fragrance and masking the bitterness, together with modifying flavours, as well as pharmacological activities such as antioxidant, anti-inflammatory, hypolipidemic and has potential for development in the fields of food and pharmaceutical. NHDC is usually obtained by hydrogenated reduction of neohesperidin (NHP) after hydrolysis under alkaline conditions, while neohesperidin is synthesized from hesperidin (HSD) and naringenin (NRG), they are called as synthesis precursors of NHDC. The synthetic precursors of NHDC have various biological activities, including antioxidant, liver and kidney protection, antibacterial and improving gastrointestinal function, etc. The pharmacological effects of NHDC are characterized by slow development process, lack of research systems and lack of depth of mechanisms compared to other dihydrochalcone compounds. In this paper, we searches the scientific databases including SciFinder, Web of Science and CNKI with the keywords of NHDC and its synthetic precursors, and reads its relevant literature. The pharmacological activity is systematically discussed and synthetic precursors mechanism is summarized for the NHDC, which will provide reference for the further utilization and development of NHDC and produce high value-added products in future.

     

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