Abstract: : Bifidobacterium, Lactobacillus and Bacillus are important members of probiotics and have great development potential. They can not only regulate the intestinal microecological balance and prevent diseases as the dominant bacteria, but also produce compounds such as bacteriocins and polysaccharides with broad-spectrum antibacterial activity. Some of these compounds also have antitumor and antioxidant properties. These characteristics make these compounds and strains to be developed into potential dietary supplements and functional foods. However, the structure, activity, mechanism and safety of many compounds are still unclear. This review summarizes the bacteriocins and polysaccharides compounds isolated from Bifidobacterium, Lactobacillus and Bacillus with probiotic potential from 2010 to 2019, and reviews their classification, structure, antibacterial, antitumor, antioxidant activities and other functions, which provide a reference for the development and application of strains and their metabolites.