Abstract: In recent years, allergies caused by consumption of aquatic products are increasing, due to a spurt processing in consumption of aquatic products. Food allergy is an important public health issue around the world. Therefore, the hypoallergenic or non-allergenic food by processed technology is of critical significance to allergic people. The research progress of aquatic products allergen processing and reduction technology are summarized in this article. The main types of aquatic product allergens and details of different food processing technologies effects on aquatic products allergens are introduced. The hypoallergenic aquatic products research status and development trends are analyzed in order to provide guidance for the future research.