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中国精品科技期刊2020
王玲芝,唐建开,王舒恒,等. 连翘叶提取物对热应激大鼠的保护作用[J]. 食品工业科技,2021,42(17):343−349. doi: 10.13386/j.issn1002-0306.2020090052.
引用本文: 王玲芝,唐建开,王舒恒,等. 连翘叶提取物对热应激大鼠的保护作用[J]. 食品工业科技,2021,42(17):343−349. doi: 10.13386/j.issn1002-0306.2020090052.
WANG Lingzhi, TANG Jiankai, WANG Shuheng, et al. Protective Effect of Forsythia suspensa Leaf Extracts on Heat-stressed Rats[J]. Science and Technology of Food Industry, 2021, 42(17): 343−349. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020090052.
Citation: WANG Lingzhi, TANG Jiankai, WANG Shuheng, et al. Protective Effect of Forsythia suspensa Leaf Extracts on Heat-stressed Rats[J]. Science and Technology of Food Industry, 2021, 42(17): 343−349. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020090052.

连翘叶提取物对热应激大鼠的保护作用

Protective Effect of Forsythia suspensa Leaf Extracts on Heat-stressed Rats

  • 摘要: 探讨连翘叶提取物对热应激大鼠的保护作用。将30只大鼠随机分为空白对照组、热应激模型组以及连翘叶提取物低、中、高剂量组,采用人工智能气候箱建立大鼠热应激模型。热应激实验结束时,分析各组大鼠生长性能、器官指数等指标,观察大鼠回肠及肝组织病理学变化,并检测血清中血清中皮质酮(Corticosterone, CORT)和促肾上腺皮质激素(Adrenocorticotropic hormone, ACTH)的含量等。结果表明:与模型组相比,连翘叶提取物高剂量组免疫器官指数显著提高(P<0.05),CORT和ACTH的含量显著降低(P<0.05),大鼠回肠及肝组织损伤得到明显的改善。此研究表明连翘叶提取物对热应激大鼠具有一定的保护作用,可用于预防高热中暑。

     

    Abstract: To study the protective effect of Forsythia suspensa leaf extract (FSLE) on heat-stressed rats, thirty rats were randomly divided into control group, heat stress group, and FSLE low-dose group, FSLE medium-dose group, and FSLE high-dose group, artificial intelligent climatic chamber was uesd to establish the heat stress model of rats. At the end of the heat stress experiment, the growth performance, rectal temperature, organ index and other indicators of the rats in each group were analyzed. The pathological changes of the rats ileum and liver tissues were observed, and the contents of corticosterone (CORT) and adrenocorticotropic hormone (ACTH) in the serum were detected. The results showed that compared with the model group, the immune organ index of the FSLE high-dose group increased significantly(P<0.05). The levels of CORT and ACTH in serum were significantly reduced(P<0.05), and the injury of rats ileum and liver tissue was significantly improved. This study showed that FSLE had a certain protective effect on heat-stressed rats, and it could be used for the prevention of heat stroke.

     

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