Abstract: The protective effects of three kinds of Hericium erinaceus oral liquids on gastric mucosal injury were compared based on gastric mucosal injury models in rats, and the acute injury indexs and chronic ulcer indexs of gastric mucosa were explained in detail. The results showed that all three oral liquid samples could protect the gastric mucosa. In the acute injury model, when the sample concentration was low, there was no significant difference in the gastroprotective effects of three samples, and the efficacy of samples increased as the concentration increased. Among them, when the dose was 10.00 mL/kg, the efficacy of Hericium erinaceus oral liquids B (itspolysaccharide contents ≥ 200 mg/100 mL) was the best, and its inhibition rate of injury was 33.66%. In the chronic injury model, showed that when the dose was 10.00 mL/kg, the Hericium erinaceus oral liquids A (polysaccharide contents ≥ 120 mg/100 mL) was superior to the other two samples, and it could reduce the ulcer area of gastric mucosa of rats to 0.181±0.056 mm².The above results showed that Hericium erinaceus oral liquids B (polysaccharide contents ≥ 200 mg/100 mL) and Hericium erinaceus oral liquids A (polysaccharide contents ≥ 120 mg/100 mL) had good gastroprotective effects on acute and chronic gastric mucosal injury in rats, respectively.