Abstract: Our country is the largest Litchi producer in the world. The planting area accounts for more than 80% of the world. As the planting amount of Litchi is increasing,the yield of Litchi Semen is also increasing gradually. But it is often discarded at will,which not only pollutes the environment,but also causes waste of resources. Litchi Semen has good medicinal value,but its quality control standard is not stipulated in the 15-year edition of Chinese pharmacopoeia. In order to improve the quality standard of Litchi Semen and enhance people's awareness of Litchi Semen protection,based on the review of its chemical composition and pharmacological effects,combined with the definition of Q-marker,this study processed predictive analysis on Q-marker of Litchi Semen from several aspects at chemical composition,new clinical use,measurable composition,traditional medicine properties and efficacy,plasma composition,and compatibility environment,which provides the basis for quality evaluation of Litchi Semen.